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Role of a cefoxitin-inducible beta-lactamase in a case of breakthrough bacteremia.

ABSTRACT

Development of resistance during therapy with cefamandole contributes to treatment failure. A simple cefoxitin disk test was recently described which detects a cefamandole-active inducible beta-lactamase not otherwise detectable with cefamandole as the inducer. A case of breakthrough Enterobacter bacteremia due to selection of a resistant subpopulation is reported in an immunocompromised patient. The use of this simple disk test in selected clinical cases is advocated.

This article has been cited by other articles:

• Olsson, J. M., Keyserling, H., Feldman, W. E. (1982). Clinical Failure of Cefamandole in the Treatment of Hemophilus Influenzae Bacteremia. CLIN PEDIATR 21: 244-245