This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Allen, P Z Articles by Robbins, J B Search for Related Content PubMed PubMed Citation Articles by Allen, P Z Articles by Robbins, J B

Identification of immunoglobulin heavy-chain isotypes of specific antibodies of horse 46 group B meningococcal antiserum.

ABSTRACT

Hyperimmune horse serum from a single animal (horse 46) immunized with group B (strain B-11) meningococcal vaccine provides a standardized, readily available diagnostic reagent used in primary isolation medium and for serogrouping of meningococci. Identification of the heavy-chain isotypes of specific anticapsular polysaccharide and anti-lipopolysaccharide isolated from horse 46 serum revealed a differential distribution in the occurrence of immunoglobulin classes. Meningococcal anticapsular antibodies of horse 46 serum were restricted predominately to the immunoglobulin M (IgM) class, with only trace amounts of IgGa present, whereas anti-lipopolysaccharide concomitantly produced showed a heterogeneity in its heavy-chain isotypes, consisting of IgM, IgGa, IgGb, moderate amounts of IgB, and a small amount of IgA.

This article has been cited by other articles:

• Cronin, N. B., O'Reilly, A., Duclohier, H., Wallace, B. A. (2003). Binding of the Anticonvulsant Drug Lamotrigine and the Neurotoxin Batrachotoxin to Voltage-gated Sodium Channels Induces Conformational Changes Associated with Block and Steady-state Activation. J. Biol. Chem. 278: 10675-10682 [Abstract] [Full Text]  
• Sato, C., Kitajima, K., Inoue, S., Seki, T., Inoue, Y. (1995). Characterization of the Antigenic Specificity of Four Different Anti-(alpha2[IMAGE]8-Linked Polysialic Acid) Antibodies Using Lipid-conjugated Oligo/Polysialic Acids. J. Biol. Chem. 270: 18923-18928 [Abstract] [Full Text]