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Indirect fluorescent-antibody technique for serological diagnosis of La Crosse (California) virus infections.

ABSTRACT

A clinically relevant indirect fluorescent-antibody technique (IFA) was developed for the serological diagnosis of La Crosse virus infections. The IFA (67%) was as sensitive as the hemagglutination inhibition (58%) and neutralization (58%) tests in the detection of antibodies in acute-phase specimens. Immunoglobulin M antibodies were detected by the IFA test in 48% (11 of 23) of these specimens. Diagnostically significant increases in IFA titer were detected in 86% (19 of 22) of the paired samples. Antibodies were detectable in some patients 7 years after infection; however, the IFA test was not as sensitive as the other two tests in the detection of previous infections.

This article has been cited by other articles:

• Rust, R. S., Thompson, W. H., Matthews, C. G., Beaty, B. J., Chun, R. W.M. (1999). Topical Review: La Crosse and Other Forms of California Encephalitis. J Child Neurol 14: 1-14 [Abstract]