This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Berkelman, R L Articles by Anderson, R L Search for Related Content PubMed PubMed Citation Articles by Berkelman, R L Articles by Anderson, R L

Increased bactericidal activity of dilute preparations of povidone-iodine solutions.

ABSTRACT

Recent confirmation of intrinsic bacterial contamination of 10% povidone-iodine solution has raised questions regarding the bactericidal mechanism of iodophors and the possibility for survival of vegetative bacterial cells in iodophor solutions. In this laboratory investigation, five different species were exposed to various dilutions of three commercial preparations of 10% povidone-iodine solution; survival was assessed after exposure for time periods varying between 0 and 8 min. All brands of povidone-iodine solution tested demonstrated more rapid killing of Staphylococcus aureus and Mycobacterium chelonei at dilutions of 1:2, 1:4, 1:10, 1:50, and 1:100 than did the stock solutions, S. aureus survived a 2-min exposure to full-strength povidone-iodine solution but did not survive a 15-s exposure to a 1:100 dilution of the iodophor. Both stock and dilute preparations of 10% povidone-iodine solution demonstrated rapid bactericidal action against Klebsiella pneumoniae, Pseudomonas cepacia, and Streptococcus mitis.

This article has been cited by other articles:

• Isenberg, S J, Apt, L, Del Signore, M, Gichuhi, S, Berman, N G (2003). A double application approach to ophthalmia neonatorum prophylaxis. Br. J. Ophthalmol. 87: 1449-1452 [Abstract] [Full Text]  
• Ferguson, A W, Scott, J A, McGavigan, J, Elton, R A, McLean, J, Schmidt, U, Kelkar, R, Dhillon, B (2003). Comparison of 5% povidone-iodine solution against 1% povidone-iodine solution in preoperative cataract surgery antisepsis: a prospective randomised double blind study. Br. J. Ophthalmol. 87: 163-167 [Abstract] [Full Text]  
• Pels, E, Vrensen, G F J M (1999). Microbial decontamination of human donor eyes with povidone-iodine: penetration, toxicity, and effectiveness. Br. J. Ophthalmol. 83: 1019-1026 [Abstract] [Full Text]