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J Clin Microbiol. 1983 November; 18(5): 1237-1243

Monoclonal antibodies against hepatitis A virus.

A MacGregor, M Kornitschuk, J G Hurrell, N I Lehmann, A G Coulepis, S A Locarnini and I D Gust

ABSTRACT

Three monoclonal antibodies (K2-4F2, K3-2F2, and K3-4C8) of the immunoglobulin G2a class were raised against hepatitis A virus. The specificity of these antibodies was confirmed by immune electron microscopy, solid-phase radioimmunoassay, and in vitro neutralization in cell culture. Binding studies suggested that they all recognize closely related antigenic determinants. These monoclonal antibodies should prove to be of great value as diagnostic and research reagents.

J Clin Microbiol. 1983 November; 18(5): 1237-1243




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1983 by the American Society for Microbiology. All rights reserved.