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J Clin Microbiol. 1984 January; 19(1): 21-25

Enzyme-linked immunosorbent assay compared with neutralization tests for evaluation of live mumps vaccines.

ABSTRACT

Mumps-specific antibody levels before and after vaccination with live mumps vaccines were determined by enzyme-linked immunosorbent assay (ELISA) and neutralization tests. A correlation was found between neutralization titers and optical density in ELISA. However, postvaccination sera from some vaccinees who failed to seroconvert by neutralization contained significant levels of mumps-specific antibody detectable by ELISA. In some of these serum specimens, the antibody directed to the F polypeptide of mumps virus was predominant. Most sera positive in ELISA neutralized mumps virus upon the addition of fresh guinea pig serum to the virus-serum mixture.

This article has been cited by other articles:

• Backhouse, J. L., Gidding, H. F., McIntyre, P. B., Gilbert, G. L. (2006). Evaluation of Two Enzyme Immunoassays for Detection of Immunoglobulin G Antibodies to Mumps Virus.. CVI 13: 764-767 [Abstract] [Full Text]