This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bille, J Articles by Roberts, G D Search for Related Content PubMed PubMed Citation Articles by Bille, J Articles by Roberts, G D

 Previous Article  |  Next Article 

J Clin Microbiol. 1984 February; 19(2): 126-128

Clinical evaluation of the lysis-centrifugation blood culture system for the detection of fungemia and comparison with a conventional biphasic broth blood culture system.

ABSTRACT

In a comparative fungal blood culture study, a lysis-centrifugation system (Isolator; Du Pont Co., Wilmington, Del.) detected 89% of all episodes of fungemia; the lysis-centrifugation system detected fungemia exclusively or significantly earlier than did a biphasic brain heart infusion bottle system 83% of the time. The lysis-centrifugation system was particularly useful in the early detection of fungemia caused by Candida tropicalis and Candida glabrata. In 53% of the clinically significant episodes, the earlier detection was directly helpful in the management of patients with fungemia. High-magnitude candidemia (greater than 5 CFU/ml of blood) was significantly associated with the presence of an infected intravascular catheter and with Candida species other than Candida albicans. The lysis-centrifugation system was sensitive in the detection of fungemia during the monitoring of patients receiving antifungal agents or after removal of an infected intravascular catheter.

This article has been cited by other articles:

• Ben-Ami, R., Weinberger, M., Orni-Wasserlauff, R., Schwartz, D., Itzhaki, A., Lazarovitch, T., Bash, E., Aharoni, Y., Moroz, I., Giladi, M. (2008). Time to Blood Culture Positivity as a Marker for Catheter-Related Candidemia. J. Clin. Microbiol. 46: 2222-2226 [Abstract] [Full Text]  
• Creger, R., Weeman, K., Jacobs, M., Morrissey, A, Parker, P, Fox, R., Lazarus, H. (1998). Lack of utility of the lysis-centrifugation blood culture method for detection of fungemia in immunocompromised cancer patients [In Process Citation]. J. Clin. Microbiol. 36: 290-293 [Abstract] [Full Text]