This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lewis, V J Articles by Winkler, W G Search for Related Content PubMed PubMed Citation Articles by Lewis, V J Articles by Winkler, W G

 Previous Article  |  Next Article 

J Clin Microbiol. 1975 September; 2(3): 193-197

Comparison of three tests for the serological diagnosis of lymphocytic choriomeningitis virus infection.

ABSTRACT

Levels of lymphocytic choriomeningitis virus antibody were assayed in 62 infected persons. The three tests used were indirect fluorescent antibody (IFA), complement fixation, and neutralization in mice. The sera first became positive by the IFA test, and IFA titers rapidly rose to a relatively high level, with the sera remaining positive long after the antibody detectable by complement fixation had disappeared. The IFA test appeared to be specific. The sera became positive last by the mouse neutralization test; with this test, antibody first appeared several weeks after infection. Virus-infected cells were stable when stored at -60 C, allowing diagnostic sera to be tested promptly by the IFA test. The IFA test for lymphocytic choriomeningitis antibody should increase the number of serological diagnoses, since it is not only rapid and specific, but detects cases not diagnosed by the other methods.

This article has been cited by other articles:

• Barton, L. L., Hyndman, N. J. (2000). Lymphocytic Choriomeningitis Virus: Reemerging Central Nervous System Pathogen. Pediatrics 105: 35e-35 [Abstract] [Full Text]