This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Partanen, P Articles by Leinikki, P O Search for Related Content PubMed PubMed Citation Articles by Partanen, P Articles by Leinikki, P O

 Previous Article  |  Next Article 

J Clin Microbiol. 1984 July; 20(1): 133-135

Immunoblot analysis of Toxoplasma gondii antigens by human immunoglobulins G, M, and A antibodies at different stages of infection.

ABSTRACT

The Toxoplasma gondii antigenic components eliciting the immunoglobulin G (IgG), IgM, and IgA antibody responses were studied by using follow-up sera from a laboratory worker who developed an acute glandular toxoplasmosis after an accidental infection with the protozoa. IgG toxoplasma antibodies reacted with multiple components over a wide molecular weight range from 6,000 to 150,000. In contrast, IgM toxoplasma antibodies reacted predominantly with polypeptides of 6, 25, and 35 kilodaltons, which might be useful in new diagnostic procedures. The general pattern of antigenic components in the IgA toxoplasma antibody response closely resembled that in the IgM response, even though some characteristic features were constantly observed. The possibility that the restricted IgM and IgA antibody responses relate to the pathogenetic events in human toxoplasmosis is considered.

This article has been cited by other articles:

• Saeij, J. P. J., Arrizabalaga, G., Boothroyd, J. C. (2008). A Cluster of Four Surface Antigen Genes Specifically Expressed in Bradyzoites, SAG2CDXY, Plays an Important Role in Toxoplasma gondii Persistence. Infect. Immun. 76: 2402-2410 [Abstract] [Full Text]  
• Kim, S.-K., Karasov, A., Boothroyd, J. C. (2007). Bradyzoite-Specific Surface Antigen SRS9 Plays a Role in Maintaining Toxoplasma gondii Persistence in the Brain and in Host Control of Parasite Replication in the Intestine. Infect. Immun. 75: 1626-1634 [Abstract] [Full Text]  
• Kim, S.-K., Boothroyd, J. C. (2005). Stage-Specific Expression of Surface Antigens by Toxoplasma gondii as a Mechanism to Facilitate Parasite Persistence. J. Immunol. 174: 8038-8048 [Abstract] [Full Text]  
• Joseph, P., Calderon, M. M., Gilman, R. H., Quispe, M. L., Cok, J., Ticona, E., Chavez, V., Jimenez, J. A., Chang, M. C., Lopez, M. J., Evans, C. A. (2002). Optimization and Evaluation of a PCR Assay for Detecting Toxoplasmic Encephalitis in Patients with AIDS. J. Clin. Microbiol. 40: 4499-4503 [Abstract] [Full Text]  
• CONTINI, C., CULTRERA, R., SERACENI, S., SEGALA, D., ROMANI, R., FAINARDI, E., CINQUE, P., LAZZARIN, A., DELIA, S. (2002). The role of stage-specific oligonucleotide primers in providing effective laboratory support for the molecular diagnosis of reactivated Toxoplasma gondii encephalitis in patients with AIDS. J Med Microbiol 51: 879-890 [Abstract] [Full Text]  
• Herwaldt, B. L. (2001). Laboratory-Acquired Parasitic Infections from Accidental Exposures. Clin. Microbiol. Rev. 14: 659-688 [Abstract] [Full Text]  
• Pinon, J. M., Dumon, H., Chemla, C., Franck, J., Petersen, E., Lebech, M., Zufferey, J., Bessieres, M.-H., Marty, P., Holliman, R., Johnson, J., Luyasu, V., Lecolier, B., Guy, E., Joynson, D. H. M., Decoster, A., Enders, G., Pelloux, H., Candolfi, E. (2001). Strategy for Diagnosis of Congenital Toxoplasmosis: Evaluation of Methods Comparing Mothers and Newborns and Standard Methods for Postnatal Detection of Immunoglobulin G, M, and A Antibodies. J. Clin. Microbiol. 39: 2267-2271 [Abstract] [Full Text]  
• SUZUKI, L. A., ROCHA, R. J., ROSSI, C. L. (2001). Evaluation of serological markers for the immunodiagnosis of acute acquired toxoplasmosis. J Med Microbiol 50: 62-70 [Abstract] [Full Text]