This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Andersen, A B Articles by Bennedsen, J Search for Related Content PubMed PubMed Citation Articles by Andersen, A B Articles by Bennedsen, J

 Previous Article  |  Next Article 

J Clin Microbiol. 1986 March; 23(3): 446-451

Interspecies reactivity of five monoclonal antibodies to Mycobacterium tuberculosis as examined by immunoblotting and enzyme-linked immunosorbent assay.

ABSTRACT

Five different murine monoclonal antibodies (MAbs) to Mycobacterium tuberculosis were examined for degree of cross-reactivity with other mycobacterial species by enzyme-linked immunosorbent assay and immunoblotting. One MAb reacted solely with M. tuberculosis and M. bovis BCG. Two of the MAbs reacted with all mycobacterial species examined, whereas two MAbs demonstrated a limited reactivity pattern. The epitopes are located on molecules susceptible to protease treatment, and two of these molecules possess concanavalin A-binding moieties. Two of the antigens defined by these five MAbs are present in tuberculin purified protein derivative.

This article has been cited by other articles:

• Brandt, L., Feino Cunha, J., Weinreich Olsen, A., Chilima, B., Hirsch, P., Appelberg, R., Andersen, P. (2002). Failure of the Mycobacterium bovis BCG Vaccine: Some Species of Environmental Mycobacteria Block Multiplication of BCG and Induction of Protective Immunity to Tuberculosis. Infect. Immun. 70: 672-678 [Abstract] [Full Text]  
• Freeman, R., Magee, J., Barratt, A., Wheeler, J., Steward, M., Lee, M., Piggott;, N., Grobusch, M. P. (1999). Rapid Immunochromatographic Assay for Diagnosis of Tuberculosis: Antibodies Detected May Not Be Specific. J. Clin. Microbiol. 37: 2111-2112 [Full Text]  
• Elhay, M. J., Oettinger, T., Andersen, P. (1998). Delayed-Type Hypersensitivity Responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the Guinea Pig. Infect. Immun. 66: 3454-3456 [Abstract] [Full Text]  
• Harboe, M., Wiker, H. G., Ulvund, G., Lund-Pedersen, B., Andersen, A. B., Hewinson, R. G., Nagai, S. (1998). MPB70 and MPB83 as Indicators of Protein Localization in Mycobacterial Cells. Infect. Immun. 66: 289-296 [Abstract] [Full Text]