This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Genta, R M Articles by Walzer, P D Search for Related Content PubMed PubMed Citation Articles by Genta, R M Articles by Walzer, P D

 Previous Article  |  Next Article 

J Clin Microbiol. 1986 June; 23(6): 1099-1103

Diagnostic implications of parasite-specific immune responses in immunocompromised patients with strongyloidiasis.

ABSTRACT

Parasite-specific humoral and cellular immune responses were evaluated in in nine immunosuppressed patients with Strongyloides stercoralis infection. Four patients had the disseminated form of the disease, and five had serious manifestations without evidence of hyperinfection. All patients had high levels of immunoglobulin G (IgG) antibodies directed against S. stercoralis larval antigens as detected by the enzyme-linked immunosorbent assay. Seven patients had both elevated total serum IgE and parasite-specific IgE antibodies detected by a modified radioimmunoassay. The hyperinfected patients differed significantly from the nonhyperinfected group in total and specific IgE levels and peripheral eosinophilia but not in specific IgG levels. None of the patients tested exhibited significant in vitro lymphoproliferative responses to parasite antigens. Our results indicated that the possibility of a protective role of IgE and eosinophils in strongyloidiasis deserves further investigation. In addition, we suggest that the enzyme-linked immunosorbent assay for specific IgG antibodies may have an important place in the diagnosis of strongyloidiasis in immunocompetent as well as in immunocompromised patients.

This article has been cited by other articles:

• Lim, S., Katz, K., Krajden, S., Fuksa, M., Keystone, J. S., Kain, K. C. (2004). Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management. CMAJ 171: 479-484 [Abstract] [Full Text]  
• Lowichik, A., Ruff, A. J. (1995). Topical Review: Parasitic Infections of the Central Nervous System in Children. Part II: Disseminated Infections. J Child Neurol 10: 77-87 [Abstract]