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J Clin Microbiol. 1986 June; 23(6): 1134-1135

Imipenem susceptibility testing with a commercially prepared dry-format microdilution tray.

ABSTRACT

MICs of imipenem, concurrently generated in commercially prepared microdilution trays containing predried antibiotic dilutions (Sensititre), and in a standard agar dilution assay (as recommended by the National Committee for Clinical Laboratory Standards, Villanova, Pa.), were within +/- 1 twofold dilution for 94% of 226 bacterial isolates. Imipenem biological activity remained stable over 5 months of tray storage at room temperature against Pseudomonas aeruginosa ATCC 27853. Activity of imipenem was shown by microdilution testing with 890 clinical isolates to be high, with only 4% of isolates having MICs of greater than or equal to 16 micrograms/ml (in vitro resistance).

This article has been cited by other articles:

• Chapin, K. C., Musgnug, M. C. (2003). Validation of the Automated Reading and Incubation System with Sensititre Plates for Antimicrobial Susceptibility Testing. J. Clin. Microbiol. 41: 1951-1956 [Abstract] [Full Text]