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J Clin Microbiol. 1987 October; 25(10): 1854-1859

Cross-reactions between pneumococci and other streptococci due to C polysaccharide and F antigen.

World Health Organization Collaborating Centre for Reference and Research on Pneumococci, Statens Seruminstitut, Copenhagen S, Denmark.

ABSTRACT

By serological methods, all 83 known types of Streptococcus pneumoniae could be shown to possess C polysaccharide and F antigen. Cross-reactions due to these two antigens between pneumococci and a broad range of most other commonly encountered streptococci were examined. The presence of an antigen closely similar or identical to pneumococcal C polysaccharide was demonstrated in some strains of Streptococcus mitior. Therefore, we conclude that pneumococci cannot be identified serologically from mixed samples without culture. Streptococcal group C antiserum was found to cross-react with pneumococcal F antigen.

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