This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Okuno, T Articles by Baba, K Search for Related Content PubMed PubMed Citation Articles by Okuno, T Articles by Baba, K

 Previous Article  |  Next Article 

J Clin Microbiol. 1989 April; 27(4): 651-653

Seroepidemiology of human herpesvirus 6 infection in normal children and adults.

Department of Virology, Osaka University, Japan.

ABSTRACT

Sera from normal subjects were examined for reactivity to human herpesvirus 6 (HHV-6) by the anticomplement immunofluorescence test. Of a total of 179 serum specimens from donors aged from under 10 to 59 years, 141 specimens showed positive reactivity against HHV-6. The positive rate was 70 to 83% for all age groups, and there were no substantial differences in the positive rates. Sera from younger children aged from 0 to 21 months were then examined in detail. The antibody-positive rate of children aged from 0 to 5 months decreased from 52 to 5%, but it gradually increased by 12 months. Almost all children had the antibody against this virus after 13 months of age.

This article has been cited by other articles:

• Flamand, L., Gravel, A., Boutolleau, D., Alvarez-Lafuente, R., Jacobson, S., Malnati, M. S., Kohn, D., Tang, Y.-W., Yoshikawa, T., Ablashi, D. (2008). Multicenter Comparison of PCR Assays for Detection of Human Herpesvirus 6 DNA in Serum. J. Clin. Microbiol. 46: 2700-2706 [Abstract] [Full Text]  
• Kofod-Olsen, E., Ross-Hansen, K., Mikkelsen, J. G., Hollsberg, P. (2008). Human herpesvirus 6B U19 protein is a PML-regulated transcriptional activator that localizes to nuclear foci in a PML-independent manner. J. Gen. Virol. 89: 106-116 [Abstract] [Full Text]  
• Seeley, W. W., Marty, F. M., Holmes, T. M., Upchurch, K., Soiffer, R. J., Antin, J. H., Baden, L. R., Bromfield, E. B. (2007). Post-transplant acute limbic encephalitis: Clinical features and relationship to HHV6. Neurology 69: 156-165 [Abstract] [Full Text]  
• Jaworska, J., Gravel, A., Fink, K., Grandvaux, N., Flamand, L. (2007). Inhibition of Transcription of the Beta Interferon Gene by the Human Herpesvirus 6 Immediate-Early 1 Protein. J. Virol. 81: 5737-5748 [Abstract] [Full Text]  
• Opsahl, M. L., Kennedy, P. G. E. (2005). Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter. Brain 128: 516-527 [Abstract] [Full Text]  
• Zerr, D. M., Meier, A. S., Selke, S. S., Frenkel, L. M., Huang, M.-L., Wald, A., Rhoads, M. P., Nguy, L., Bornemann, R., Morrow, R. A., Corey, L. (2005). A Population-Based Study of Primary Human Herpesvirus 6 Infection. NEJM 352: 768-776 [Abstract] [Full Text]  
• De Bolle, L., Naesens, L., De Clercq, E. (2005). Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy. Clin. Microbiol. Rev. 18: 217-245 [Abstract] [Full Text]  
• Vuorinen, T., Kotilainen, P., Lautenschlager, I., Kujari, H., Krogerus, L., Oksi, J. (2004). Interstitial Pneumonitis and Coinfection of Human Herpesvirus 6 and Pneumocystis carinii in a Patient with Hypogammaglobulinemia. J. Clin. Microbiol. 42: 5415-5418 [Abstract] [Full Text]  
• Borenstein, R., Singer, O., Moseri, A., Frenkel, N. (2004). Use of Amplicon-6 Vectors Derived from Human Herpesvirus 6 for Efficient Expression of Membrane-Associated and -Secreted Proteins in T Cells. J. Virol. 78: 4730-4743 [Abstract] [Full Text]  
• Kano, Y., Inaoka, M., Shiohara, T. (2004). Association Between Anticonvulsant Hypersensitivity Syndrome and Human Herpesvirus 6 Reactivation and Hypogammaglobulinemia. Arch Dermatol 140: 183-188 [Abstract] [Full Text]  
• Wong, G. A. E., Shear, N. H. (2004). Is a Drug Alone Sufficient to Cause the Drug Hypersensitivity Syndrome?. Arch Dermatol 140: 226-230 [Full Text]  
• Dockrell, D.H. (2003). Human herpesvirus 6: molecular biology and clinical features. J Med Microbiol 52: 5-18 [Abstract] [Full Text]  
• Sashihara, J., Tanaka-Taya, K., Tanaka, S., Amo, K., Miyagawa, H., Hosoi, G., Taniguchi, T., Fukui, T., Kasuga, N., Aono, T., Sako, M., Hara, J., Yamanishi, K., Okada, S. (2002). High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients. Blood 100: 2005-2011 [Abstract] [Full Text]  
• Takemoto, M., Shimamoto, T., Isegawa, Y., Yamanishi, K. (2001). The R3 Region, One of Three Major Repetitive Regions of Human Herpesvirus 6, Is a Strong Enhancer of Immediate-Early Gene U95. J. Virol. 75: 10149-10160 [Abstract] [Full Text]  
• Ozaki, Y., Tajiri, H., Tanaka-Taya, K., Mushiake, S., Kimoto, A., Yamanishi, K., Okada, S. (2001). Frequent Detection of the Human Herpesvirus 6-Specific Genomes in the Livers of Children with Various Liver Diseases. J. Clin. Microbiol. 39: 2173-2177 [Abstract] [Full Text]  
• Locatelli, G., Santoro, F., Veglia, F., Gobbi, A., Lusso, P., Malnati, M. S. (2000). Real-Time Quantitative PCR for Human Herpesvirus 6 DNA. J. Clin. Microbiol. 38: 4042-4048 [Abstract] [Full Text]  
• Zerr, D. M., Huang, M.-L., Corey, L., Erickson, M., Parker, H. L., Frenkel, L. M. (2000). Sensitive Method for Detection of Human Herpesviruses 6 and 7 in Saliva Collected in Field Studies. J. Clin. Microbiol. 38: 1981-1983 [Abstract] [Full Text]  
• Friedman, J E, Lyons, M J, Cu, G, Ablashl, D V, Whitman, J E, Edgar, M, Koskiniemi, M., Vaheri, A., Zabriskie, J B (1999). The association of the human herpesvirus-6 and MS. Mult Scler 5: 355-362 [Abstract]  
• Asada, H., Klaus-Kovtun, V., Golding, H., Katz, S. I., Blauvelt, A. (1999). Human Herpesvirus 6 Infects Dendritic Cells and Suppresses Human Immunodeficiency Virus Type 1 Replication in Coinfected Cultures. J. Virol. 73: 4019-4028 [Abstract] [Full Text]  
• Faulkner, G. C., Burrows, S. R., Khanna, R., Moss, D. J., Bird, A. G., Crawford, D. H. (1999). X-Linked Agammaglobulinemia Patients Are Not Infected with Epstein-Barr Virus: Implications for the Biology of the Virus. J. Virol. 73: 1555-1564 [Abstract] [Full Text]  
• Drago, F., Rebora, A. (1999). The New Herpesviruses: Emerging Pathogens of Dermatological Interest. Arch Dermatol 135: 71-75 [Abstract] [Full Text]  
• Suga, S., Yoshikawa, T., Kajita, Y., Ozaki, T., Asano, Y. (1998). Prospective Study of Persistence and Excretion of Human Herpesvirus-6 in Patients With Exanthem Subitum and Their Parents. Pediatrics 102: 900-904 [Abstract] [Full Text]  
• Luppi, M., Barozzi, P., Garber, R., Maiorana, A., Bonacorsi, G., Artusi, T., Trovato, R., Marasca, R., Torelli, G. (1998). Expression of Human Herpesvirus-6 Antigens in Benign and Malignant Lymphoproliferative Diseases. Am. J. Pathol. 153: 815-823 [Abstract] [Full Text]  
• Tohyama, M., Yahata, Y., Yasukawa, M., Inagi, R., Urano, Y., Yamanishi, K., Hashimoto, K. (1998). Severe Hypersensitivity Syndrome Due to Sulfasalazine Associated With Reactivation of Human Herpesvirus 6. Arch Dermatol 134: 1113-1117 [Abstract] [Full Text]  
• Hukin, J., Farrell, K., MacWilliam, L. M, Colbourne, M., Waida, E., Tan, R., Mroz, L., Thomas, E. (1998). Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures. Pediatrics 101 : e3-e3 [Abstract] [Full Text]  
• Osiowy, C, Prud'homme, I, Monette, M, Zou, S (1998). Detection of human herpesvirus 6 DNA in serum by a microplate PCR- hybridization assay [In Process Citation]. J. Clin. Microbiol. 36: 68-72 [Abstract] [Full Text]  
• Drobyski, W. R., Knox, K. K., Majewski, D., Carrigan, D. R. (1994). Fatal Encephalitis Due to Variant B Human Herpesvirus-6 Infection in a Bone Marrow-Transplant Recipient. NEJM 330: 1356-1360 [Full Text]  
• Akashi, K., Eizuru, Y., Sumiyoshi, Y., Minematsu, T., Hara, S., Harada, M., Kikuchi, M., Niho, Y., Minamishima, Y. (1993). Severe Infectious Mononucleosis-like Syndrome and Primary Human Herpesvirus 6 Infection in an Adult. NEJM 329: 168-171 [Full Text]