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J Clin Microbiol. 1989 April; 27(4): 770-772

Increased detection of herpes simplex virus in MRC-5 cells treated with dimethyl sulfoxide and dexamethasone.

P G West, B Aldrich, R Hartwig and G J Haller

SmithKline Bio-Science Laboratories, Norristown, Pennsylvania 19403.

ABSTRACT

Treatment of MRC-5 cells with dexamethasone, dimethyl sulfoxide, or a combination of the two enhanced the detection of herpes simplex virus by three- to fourfold in these cells. Fluorescent plaques were noticeably larger on cover slips treated with the enhancing agents. Low-positive clinical specimens were stored and tested in parallel in treated and untreated shell vials, and 6 to 40% of these stained positive in the treated cultures but not in the untreated controls. In standard tube cultures, cytopathic effect began earlier and was more extensive in treated tubes.

J Clin Microbiol. 1989 April; 27(4): 770-772






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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1989 by the American Society for Microbiology. All rights reserved.