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J Clin Microbiol. 1989 August; 27(8): 1893-1895

Sensitivity and specificity of pooled versus individual sera in a human immunodeficiency virus antibody prevalence study.

Public Health Laboratory, Alameda County Health Care Services Agency, Oakland, California 94607.

ABSTRACT

We evaluated the efficacy of testing pooled versus individual sera for the detection of human immunodeficiency virus antibody. A total of 5,000 individual specimens and 500 pools of 10 specimens each were assayed by an enzyme-linked immunosorbent assay. There was complete agreement in human immunodeficiency virus enzyme-linked immunosorbent assay reactivity for pooled versus individual specimens. An estimated savings of 60 to 80% (labor and supplies) can be realized dependent upon pooling and assay format.

This article has been cited by other articles:

• Novack, L., Galai, N., Yaari, A., Orgel, M., Shinar, E., Sarov, B. (2006). Use of seroconversion panels to estimate delay in detection of anti-human immunodeficiency virus antibodies by enzyme-linked immunosorbent assay of pooled compared to singleton serum samples.. J. Clin. Microbiol. 44: 2909-2913 [Abstract] [Full Text]