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J Clin Microbiol. 1990 March; 28(3): 596-599

Use of live cold-adapted influenza A H1N1 and H3N2 virus vaccines in seropositive adults.

Department of Medicine, University of Rochester School of Medicine, New York 14642.

ABSTRACT

To investigate the immunogenicity and protective efficacy of cold-adapted influenza vaccine in individuals with underlying immunity to influenza A virus, we administered cold-adapted H1N1 and H3N2 vaccines to adults with prevaccination serum hemagglutination inhibition antibody titers of 1:16 or more and challenged them 1 month afterwards with homologous wild-type influenza A virus. Both cold-adapted vaccines were immunogenic in seropositive adults. In addition, individuals receiving cold-adapted vaccines had lower rates of virus shedding and illness following challenge with wild-type influenza virus than did unvaccinated seropositive volunteers.

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