This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Short, J A Articles by Andersen, F L Search for Related Content PubMed PubMed Citation Articles by Short, J A Articles by Andersen, F L

 Previous Article  |  Next Article 

J Clin Microbiol. 1990 July; 28(7): 1635-1639

Immunoglobulin E and G4 antibodies in cysticercosis.

Department of Pediatrics, Harbor-UCLA Medical Center, Torrance 90509.

ABSTRACT

The importance of immunoglobulin G (IgG) subclass responses in different infections has been elucidated for a number of organisms, but few parasitic organisms have been examined in this regard. In the current study, quantitative radioimmunoassays were used to examine the IgE and IgG4 subclass responses to larval Taenia solium. Patients were divided into clinically infected (CI) and probably uninfected (PU) groups. Unexposed normal subjects were used as controls. The CI group had elevated geometric mean levels of total IgE in serum (28.6 IU/ml) and specific IgG4 antibodies (438.8 arbitrary units [AU]/ml) compared with controls (8.3 IU/ml and 50.1 AU/ml, respectively). The CI group also had significantly elevated levels in cerebrospinal fluid of total IgG4 (18.6 micrograms/ml) and specific IgG4 antibodies (86.0 AU/ml) compared with the PU group (2.5 micrograms/ml and 1.6 AU/ml, respectively). There was no specific IgE antibody response detected in either the CI or PU patient group. The marked IgG4 response of CI patients to T. solium merits further investigation.

This article has been cited by other articles:

• LAWN, S. D., BLIGH, J., CRAIG, P. S., CHIODINI, P. L. (2004). HUMAN CYSTIC ECHINOCOCCOSIS: EVALUATION OF POST-TREATMENT SEROLOGIC FOLLOW-UP BY IgG SUBCLASS ANTIBODY DETECTION. Am J Trop Med Hyg 70: 329-335 [Abstract] [Full Text]  
• Kong, Y., Ito, A., Yang, H.-J., Chung, Y.-B., Kasuya, S., Kobayashi, M., Liu, Y.-H., Cho, S.-Y. (1998). Immunoglobulin G (IgG) Subclass and IgE Responses in Human Paragonimiases Caused by Three Different Species. CVI 5: 474-478 [Abstract] [Full Text]