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J Clin Microbiol. 1990 August; 28(8): 1744-1746

Elevated levels of CD4 antigen in sera of human immunodeficiency virus-infected populations.

R. A. Cooke Institute of Allergy, St. Luke's Roosevelt Hospital Center, New York, New York 10019.

ABSTRACT

CD4 antigen levels in sera from asymptomatic intravenous drug users and homosexuals and patients with lymphadenopathy, acquired immunodeficiency syndrome-related complex, or acquired immunodeficiency syndrome were quantitated. Like soluble CD8, CD4 antigen levels were elevated in human immunodeficiency virus-seronegative asymptomatic intravenous drug users and homosexuals, probably reflecting infections such as cytomegalovirus, Epstein-Barr virus, and hepatitis B virus infections. The sera from human immunodeficiency virus-seropositive groups of patients with human immunodeficiency virus infection also had elevated levels of CD4 antigen, presumably reflecting infections like cytomegalovirus and human immunodeficiency virus infections.

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