This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mayo, D R Articles by Lamb, P Search for Related Content PubMed PubMed Citation Articles by Mayo, D R Articles by Lamb, P

Evaluation of a commercial measles virus immunoglobulin M enzyme immunoassay.

Biosciences Division, Connecticut State Department of Health Services, Hartford 06144.

ABSTRACT

Paired serum samples from 93 patients suspected of having measles were assayed for measles virus-specific immunoglobulin M (IgM) antibodies by an enzyme immunoassay (EIA), and the results were compared with results from a complement fixation assay and an EIA for measles virus IgG. By using significant serologic rises as the standard for comparison, the IgM EIA assay had a sensitivity of 85.7%, a specificity of 81.3%, a positive predictive value of 95.7%, and a negative predictive value of 54.2%. This assay can be expected to perform well in outbreak situations.

This article has been cited by other articles:

• Roodbari, F., Roustai, M. H., Mostafaie, A., Soleimanjdahi, H., Foroshani, R. S., Sabahi, F. (2003). Development of an Enzyme-Linked Immunosorbent Assay for Immunoglobulin M Antibodies against Measles Virus. CVI 10: 439-442 [Abstract] [Full Text]  
• Ratnam, S., Tipples, G., Head, C., Fauvel, M., Fearon, M., Ward, B. J. (2000). Performance of Indirect Immunoglobulin M (IgM) Serology Tests and IgM Capture Assays for Laboratory Diagnosis of Measles. J. Clin. Microbiol. 38: 99-104 [Abstract] [Full Text]  
• Bouche, F. B., Brons, N. H. C., Houard, S., Schneider, F., Muller, C. P. (1998). Evaluation of Hemagglutinin Protein-Specific Immunoglobulin M for Diagnosis of Measles by an Enzyme-Linked Immunosorbent Assay Based on Recombinant Protein Produced in a High-Efficiency Mammalian Expression System. J. Clin. Microbiol. 36: 3509-3513 [Abstract] [Full Text]