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J Clin Microbiol. 1991 July; 29(7): 1530-1532

Cross-reactive antibodies induced by a monovalent influenza B virus vaccine.

Division of Virology, Center for Biologics Evaluation and Research, Bethesda, Maryland 20892.

ABSTRACT

Influenza viruses related to the markedly antigenically divergent strains B/Yamagata/16/88 and B/Victoria/2/87 are circulating in human populations. Adults develop cross-reacting antibodies against recent and earlier influenza B virus strains after vaccination with B/Yamagata/16/88, probably because of previous influenza B virus infections or immunizations. Vaccines containing B/Yamagata/16/88 should adequately protect adults against B/Victoria/2/87 infections.

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