This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rosario, M Articles by Leinonen, M Search for Related Content PubMed PubMed Citation Articles by Rosario, M Articles by Leinonen, M

Evaluation of a new tube latex agglutination test for detection of type-specific pneumococcal antigens in urine.

Research Institute for Tropical Medicine, Manila, Philippines.

ABSTRACT

A modified tube agglutination test using type-specific latex reagents for detection of pneumococcal capsular polysaccharide antigens in alkalinized, unconcentrated urine samples was evaluated in reconstituted urine samples and in groups consisting of 26 children with clinical and roentgenographic evidence of acute lower respiratory tract infection, six patients with blood culture-proven infection of nonpneumococcal etiology, and 30 healthy individuals. The sensitivity of the tube latex agglutination method for pneumococcal polysaccharides was 2 to 10 times higher than that of the slide agglutination method. Positive antigen findings were obtained for 42% of urine samples from patients with acute lower respiratory tract infection but in neither patients with nonpneumococcal septicemia nor healthy controls. Fifty-five percent of the antigen-positive patients also showed evidence of pneumococcal involvement by pneumococcal antibody assay or antigen detection in acute-phase serum.

This article has been cited by other articles:

• Leeming, J. P., Cartwright, K., Morris, R., Martin, S. A., Smith, M. D., on behalf of the South-West Pneumococcus Study Gro, (2005). Diagnosis of Invasive Pneumococcal Infection by Serotype-Specific Urinary Antigen Detection. J. Clin. Microbiol. 43: 4972-4976 [Abstract] [Full Text]  
• Murdoch, D. R., Laing, R. T. R., Mills, G. D., Karalus, N. C., Town, G. I., Mirrett, S., Reller, L. B. (2001). Evaluation of a Rapid Immunochromatographic Test for Detection of Streptococcus pneumoniae Antigen in Urine Samples from Adults with Community-Acquired Pneumonia. J. Clin. Microbiol. 39: 3495-3498 [Abstract] [Full Text]