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J Clin Microbiol. 1976 April; 3(4): 438-442

Fluorescent antibody test for the serological diagnosis of gonorrhea.

H A Gaafar and D C D'Arcangelis

ABSTRACT

An indirect fluorescent antibody technique has been developed for the serological diagnosis of gonorrhea. The selected strain(s) of Neisseria gonorrhoeae possesses a heat-labile surface antigen (L-antigen). Sera are diluted 1:10, and an aliquot is hear inactivated at 59 C for 30 min. The treated and untreated aliquots are then examined for human immunoglobulin G anti-L-antigen. In a prelimiary study of 495 sera, 95% of those from women with a bacteriologically confirmed diagnosis of gorrhea and 87% of those from male patients were reactive in this test, whereas only 1.4% fo the sera from presumably normal individuals were reactive.

J Clin Microbiol. 1976 April; 3(4): 438-442






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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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