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J Clin Microbiol. 1976 April; 3(4): 460-462

Improved method for production of attenuated Venezuelan equine encephalomyelitis (TC-83 strain) vaccine.

F E Cole Jr, C E Pedersen Jr, D M Robinson and G A Eddy

ABSTRACT

Primary chicken embryo cell cultures were evaluated a s an alternate cell system for the production of attenuated Venezuelan equine encephalomyelitis (TC-83 strain) vaccine. The TC-83 strain virus was shown to remain stable during 10 serial passages in chicken embryo cell culture with regard to plaque size and morphology, virus yield, potency, and virulence for mice and hamsters.

J Clin Microbiol. 1976 April; 3(4): 460-462






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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1976 by the American Society for Microbiology. All rights reserved.