This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Westblom, T U Articles by Czinn, S J Search for Related Content PubMed PubMed Citation Articles by Westblom, T U Articles by Czinn, S J

Diagnosis of Helicobacter pylori infection in adult and pediatric patients by using Pyloriset, a rapid latex agglutination test.

Department of Medicine, St. Louis University School of Medicine, Missouri 63104.

ABSTRACT

Pyloriset (Orion Diagnostica, Espoo, Finland) is a rapid antibody test using latex particles coated with acid-extracted antigen of Helicobacter pylori. We evaluated its ability to predict infection in 100 adult patients and 50 pediatric patients referred for gastric endoscopy. Sixty of 65 H. pylori-infected adults were correctly identified by the test. There were 12 false-positive and 5 false-negative reactions seen. Pyloriset had a sensitivity of 92% and a specificity of 66%. The positive predictive value was 83% and the negative predictive value 82%. In contrast, sensitivity dropped to 36% in the pediatric patients and the positive predictive value was only 40%. Pyloriset could become an important alternative to other more time-consuming diagnostic tests for H. pylori-infected adult patients but is inadequate for diagnosis of pediatric H. pylori infection.

This article has been cited by other articles:

• Megraud, F., Lehours, P. (2007). Helicobacter pylori Detection and Antimicrobial Susceptibility Testing. Clin. Microbiol. Rev. 20: 280-322 [Abstract] [Full Text]  
• Windle, H J, Ang, Y S, Morales, V A, McManus, R, Kelleher, D (2005). Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals. Gut 54: 25-32 [Abstract] [Full Text]  
• Rocha, G. A., Oliveira, A. M. R., Queiroz, D. M. M., Carvalho, A. S. T., Nogueira, A. M. M. F. (2000). Immunoblot Analysis of Humoral Immune Response to Helicobacter pylori in Children with and without Duodenal Ulcer. J. Clin. Microbiol. 38: 1777-1781 [Abstract] [Full Text]  
• Laheij, R. J. F., Straatman, H., Jansen, J. B. M. J., Verbeek, A. L. M. (1998). Evaluation of Commercially Available Helicobacter pylori Serology Kits: a Review. J. Clin. Microbiol. 36: 2803-2809 [Full Text]