This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by De Paoli, P Articles by Santini, G Search for Related Content PubMed PubMed Citation Articles by De Paoli, P Articles by Santini, G

 Previous Article  |  Next Article 

J Clin Microbiol. 1992 March; 30(3): 729-731

Phenotypic profile and functional characteristics of human gamma and delta T cells during acute toxoplasmosis.

Department of Microbiology and Immunology, General Hospital USL11, Pordenone, Italy.

ABSTRACT

Gamma and delta (gamma delta) T-cell receptor lymphocytes are increased during acute toxoplasmosis. These cells are BB3+ CD45RO+ CD8-. Purified gamma delta T cells failed to proliferate in response to Toxoplasma gondii antigen (stimulation index, 1.4 +/- 0.6) but were responsive to phytohemagglutinin stimulation (stimulation index, 20.8 +/- 1.9). Natural-killer-like cytotoxicity was strongly acquired only after in vitro culture of purified gamma delta T cells with recombinant interleukin 2 (40% +/- 7% specific lysis). Our data show that gamma delta T-cell receptor T cells with a peculiar phenotype are increased during human acute T. gondii infection.

This article has been cited by other articles:

• Montes, C. L., Acosta-Rodriguez, E. V., Merino, M. C., Bermejo, D. A., Gruppi, A. (2007). Polyclonal B cell activation in infections: infectious agents' devilry or defense mechanism of the host?. J. Leukoc. Biol. 82: 1027-1032 [Abstract] [Full Text]  
• Egan, C. E., Dalton, J. E., Andrew, E. M., Smith, J. E., Gubbels, M.-J., Striepen, B., Carding, S. R. (2005). A Requirement for the V{gamma}1+ Subset of Peripheral {gamma}{delta} T Cells in the Control of the Systemic Growth of Toxoplasma gondii and Infection-Induced Pathology. J. Immunol. 175: 8191-8199 [Abstract] [Full Text]  
• Parissiadis, A, Dormoy, A, Fricker, D, Hanau, D, de la Salle, H, Cazenave, J-P, Lenoble, P, Donato, L (2005). Unilateral necrotising toxoplasmic retinochoroiditis as the main clinical manifestation of a peptide transporter (TAP) deficiency. Br. J. Ophthalmol. 89: 1661-1662 [Full Text]  
• Denkers, E. Y., Gazzinelli, R. T. (1998). Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection. Clin. Microbiol. Rev. 11: 569-588 [Abstract] [Full Text]