This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wayne, L G Articles by Rotter, J I Search for Related Content PubMed PubMed Citation Articles by Wayne, L G Articles by Rotter, J I

Immunoglobulin A (IgA) and IgG serum antibodies to mycobacterial antigens in Crohn's disease patients and their relatives.

Tuberculosis Research Laboratory, Department of Veterans Affairs Medical Center, Long Beach, California 90822.

ABSTRACT

Sera from patients with Crohn's disease, their relatives, their spouses, and unrelated healthy controls were assayed by enzyme-linked immunosorbent assay for immunoglobulin G (IgG) and IgA antibodies to Mycobacterium tuberculosis, M. avium, and M. gordonae. The patients had significantly higher IgA responses to mycobacterial antigens than did either their relatives or the controls. On the other hand, both the patients and their relatives had significantly higher IgG responses against these antigens than did the controls. The elevated IgA response was more pronounced against isopentanol-extracted whole bacterial cells than it was against soluble protein extracts, and it appeared to be directed against fixed surface antigens that lie under the loosely bound peptidoglycolipid or glycolipid antigens of mycobacteria.

This article has been cited by other articles:

• Wei, B., Dalwadi, H., Gordon, L. K., Landers, C., Bruckner, D., Targan, S. R., Braun, J. (2001). Molecular Cloning of a Bacteroides caccae TonB-Linked Outer Membrane Protein Identified by an Inflammatory Bowel Disease Marker Antibody. Infect. Immun. 69: 6044-6054 [Abstract] [Full Text]  
• Sutton, C L, Yang, H, Li, Z, Rotter, J I, Targan, S R, Braun, J (2000). Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease. Gut 46: 58-63 [Abstract] [Full Text]  
• Cohavy, O., Harth, G., Horwitz, M., Eggena, M., Landers, C., Sutton, C., Targan, S. R., Braun, J. (1999). Identification of a Novel Mycobacterial Histone H1 Homologue (HupB) as an Antigenic Target of pANCA Monoclonal Antibody and Serum Immunoglobulin A from Patients with Crohn's Disease. Infect. Immun. 67: 6510-6517 [Abstract] [Full Text]