This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Huber, T W Articles by Thomas, J S Search for Related Content PubMed PubMed Citation Articles by Huber, T W Articles by Thomas, J S

Detection of resistance due to inducible beta-lactamase in Enterobacter aerogenes and Enterobacter cloacae.

Department of Pathology and Laboratory Medicine, Texas A&M College of Medicine, Temple 76504.

ABSTRACT

Thirty-six of 36 strains of Enterobacter cloacae and E. aerogenes with inducible beta-lactamase developed resistance when cefoxitin (inducer) was added to cefuroxime disks. Constitutive beta-lactamase producers (n = 23) were all resistant to cefuroxime. Cefuroxime resistance correlated with the amount of induced or constitutive beta-lactamase. Cefuroxime was a better indicator of induced resistance than cefamandole, cefazolin, cephalothin, ceftriaxone, cefotaxime, ticarcillin with or without clavulanic acid, or cefotetan. Induction by addition of cefoxitin to disks occasionally reduced zone sizes but not enough to change interpretations for ceftazidime, ceftizoxime, aztreonam, cefoperazone with or without sulbactam, and piperacillin with or without tazobactam. Most enterobacters were resistant to cefmetazole. The cefoxitin inducer-cefuroxime indicator method can be used in routine clinical laboratories to detect latent resistance due to chromosomally mediated inducible beta-lactamase in enterobacters.

This article has been cited by other articles:

• Biendo, M., Canarelli, B., Thomas, D., Rousseau, F., Hamdad, F., Adjide, C., Laurans, G., Eb, F. (2008). Successive Emergence of Extended-Spectrum {beta}-Lactamase-Producing and Carbapenemase-Producing Enterobacter aerogenes Isolates in a University Hospital. J. Clin. Microbiol. 46: 1037-1044 [Abstract] [Full Text]  
• Quinteros, M., Radice, M., Gardella, N., Rodriguez, M. M., Costa, N., Korbenfeld, D., Couto, E., Gutkind, G. (2003). Extended-Spectrum {beta}-Lactamases in Enterobacteriaceae in Buenos Aires, Argentina, Public Hospitals. Antimicrob. Agents Chemother. 47: 2864-2867 [Abstract] [Full Text]  
• Navon-Venezia, S., Hammer-Munz, O., Schwartz, D., Turner, D., Kuzmenko, B., Carmeli, Y. (2003). Occurrence and Phenotypic Characteristics of Extended-Spectrum {beta}-Lactamases among Members of the Family Enterobacteriaceae at the Tel-Aviv Medical Center (Israel) and Evaluation of Diagnostic Tests. J. Clin. Microbiol. 41: 155-158 [Abstract] [Full Text]