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J Clin Microbiol. 1994 May; 32(5): 1238-1245

Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice.

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139.

ABSTRACT

A bacterium with a spiral shape and bipolar, single, sheathed flagella was isolated from the livers of mice with active, chronic hepatitis. The bacteria also colonized the cecal and colonic mucosae of mice. The bacterium grew at 37 degrees C under microaerophilic and anaerobic conditions, rapidly hydrolyzed urea, was catalase and oxidase positive, reduced nitrate to nitrite, and was resistant to cephalothin metronidazole. On the basis of 16S rRNA gene sequence analysis, the organism was classified as a novel helicobacter, Helicobacter hepaticus. This new helicobacter, like two other murine Helicobacter species, H. muridarum and "H. rappini," is an efficient colonizer of the gastrointestinal tract, but in addition, it has the pathogenic potential to elicit persistent hepatitis in mice.

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• Foley, J. E., Marks, S. L., Munson, L., Melli, A., Dewhirst, F. E., Yu, S., Shen, Z., Fox, J. G. (1999). Isolation of Helicobacter canis from a Colony of Bengal Cats with Endemic Diarrhea. J. Clin. Microbiol. 37: 3271-3275 [Abstract] [Full Text]  
• Livingston, R. S., Riley, L. K., Hook, R. R. Jr., Besch-Williford, C. L., Franklin, C. L. (1999). Cloning and Expression of an Immunogenic Membrane-Associated Protein of Helicobacter hepaticus for Use in an Enzyme-Linked Immunosorbent Assay. CVI 6: 745-750 [Abstract] [Full Text]  
• Dewhirst, F. E., Chien, C.-C., Paster, B. J., Ericson, R. L., Orcutt, R. P., Schauer, D. B., Fox, J. G. (1999). Phylogeny of the Defined Murine Microbiota: Altered Schaedler Flora. Appl. Environ. Microbiol. 65: 3287-3292 [Abstract] [Full Text]  
• Ihrig, M., Schrenzel, M. D., Fox, J. G. (1999). Differential Susceptibility to Hepatic Inflammation and Proliferation in AXB Recombinant Inbred Mice Chronically Infected with Helicobacter hepaticus. Am. J. Pathol. 155: 571-582 [Abstract] [Full Text]  
• Hickman-Davis, J., Gibbs-Erwin, J., Lindsey, J. R., Matalon, S. (1999). Surfactant protein A mediates mycoplasmacidal activity of alveolar macrophages by production of peroxynitrite. Proc. Natl. Acad. Sci. USA 96: 4953-4958 [Abstract] [Full Text]  
• Fox, J. G., Gorelick, P. L., Kullberg, M. C., Ge, Z., Dewhirst, F. E., Ward, J. M. (1999). A Novel Urease-Negative Helicobacter Species Associated with Colitis and Typhlitis in IL-10-Deficient Mice. Infect. Immun. 67: 1757-1762 [Abstract] [Full Text]  
• Andersen, L. P., Boye, K., Blom, J., Holck, S., Nørgaard, A., Elsborg, L. (1999). Characterization of a Culturable "Gastrospirillum hominis" (Helicobacter heilmannii) Strain Isolated from Human Gastric Mucosa. J. Clin. Microbiol. 37: 1069-1076 [Abstract] [Full Text]  
• Saunders, K. E., Shen, Z., Dewhirst, F. E., Paster, B. J., Dangler, C. A., Fox, J. G. (1999). Novel Intestinal Helicobacter Species Isolated from Cotton-Top Tamarins (Saguinus oedipus) with Chronic Colitis. J. Clin. Microbiol. 37: 146-151 [Abstract] [Full Text]  
• Kullberg, M. C., Ward, J. M., Gorelick, P. L., Caspar, P., Hieny, S., Cheever, A., Jankovic, D., Sher, A. (1998). Helicobacter hepaticus Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism. Infect. Immun. 66: 5157-5166 [Abstract] [Full Text]  
• Li, X., Fox, J. G., Whary, M. T., Yan, L., Shames, B., Zhao, Z. (1998). SCID/NCr Mice Naturally Infected with Helicobacter hepaticus Develop Progressive Hepatitis, Proliferative Typhlitis, and Colitis. Infect. Immun. 66: 5477-5484 [Abstract] [Full Text]  
• Shen, Z., Schauer, D. B., Mobley, H. L. T., Fox, J. G. (1998). Development of a PCR-Restriction Fragment Length Polymorphism Assay Using the Nucleotide Sequence of the Helicobacter hepaticus Urease Structural Genes ureAB. J. Clin. Microbiol. 36: 2447-2453 [Abstract] [Full Text]  
• Whary, M. T., Morgan, T. J., Dangler, C. A., Gaudes, K. J., Taylor, N. S., Fox, J. G. (1998). Chronic Active Hepatitis Induced by Helicobacter hepaticus in the A/JCr Mouse Is Associated with a Th1 Cell-Mediated Immune Response. Infect. Immun. 66: 3142-3148 [Abstract] [Full Text]  
• Tee, W., Leder, K., Karroum, E., Dyall-Smith, M. (1998). "Flexispira rappini" Bacteremia in a Child with Pneumonia. J. Clin. Microbiol. 36: 1679-1682 [Abstract] [Full Text]  
• Fox, J. G., MacGregor, J. A., Shen, Z., Li, X., Lewis, R., Dangler, C. A. (1998). Comparison of Methods of Identifying Helicobacter hepaticus in B6C3F1 Mice Used in a Carcinogenesis Bioassay. J. Clin. Microbiol. 36: 1382-1387 [Abstract] [Full Text]  
• Baker, D. G. (1998). Natural Pathogens of Laboratory Mice, Rats, and Rabbits and Their Effects on Research. Clin. Microbiol. Rev. 11: 231-266 [Abstract] [Full Text]