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Journal of Clinical Microbiology, Jul 1995, 1727-1729, Vol 33, No. 7
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Differentiation of human immunodeficiency virus type 1 (HIV-1) infections with HIV-2-cross-reacting antibody from mixed infections with HIV-1 and HIV-2 by serological absorption test

M Imai, T Hayashi, M Kondo, T Saito, A Ito, M Hayami and K Nishioka
Department of Virology, Kanagawa Prefectural Institute of Health, Yokohama, Japan.

The interpretation of dual seroreactivity with human immunodeficiency virus type 1 (HIV-1) and HIV-2 in blood samples is a serious problem facing AIDS researchers worldwide. Some samples of sera from HIV-1- infected patients showed a serological cross-reaction with HIV-2, causing confusion regarding the serodiagnosis. Therefore, we tried to differentiate these serum samples from those containing real mixed infections with both types of virus. Sera from patients with HIV-1 infections with HIV-2 cross-reacting antibody in Japan were distinguished from sera from patients with mixed infections with HIV-1 and HIV-2 in West Africa by our serological cross-absorption test, which proved to be highly specific and useful for serodiagnosis.