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Journal of Clinical Microbiology, Jul 1995, 1839-1841, Vol 33, No. 7
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Isolation and characterization of a naturally occurring parainfluenza 3 virus variant

EM Swierkosz, DD Erdman, T Bonnot, C Schneiderheinze and JL Waner
Department of Pediatrics, St. Louis University School of Medicine, MO 63104, USA.

A parainfluenza 3 virus variant which failed to react with parainfluenza 3 virus-specific monoclonal anti-bodies from two commercial sources was isolated from a 14-month-old boy. Analysis of the coding region of the hemagglutinin-neuraminidase gene identified 36 nucleotide changes and 4 amino acid changes compared with a consensus sequence derived from strains isolated from 1957 through 1983. Two unique amino acid changes occurred at positions 174 and 283, which are close to identified epitopes in the hemagglutinin-neuraminidase protein. Ongoing viral surveillance to detect variants is important, particularly in regard to vaccine development.

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