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Journal of Clinical Microbiology, Oct 1996, 2609-2612, Vol 34, No. 10
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Surrogate disks for predicting cefotaxime and ceftriaxone susceptibilities of Streptococcus pneumoniae

AL Barry and PC Fuchs
Clinical Microbiology Institute, Tualatin, Oregon 97062, USA.

Cefotaxime- and ceftriaxone-resistant Streptococcus pneumoniae is now appearing in some medical centers, but 30-micrograms cefotaxime or 30- micrograms ceftriaxone disks are not reliable for detecting such strains. Studies were undertaken to select another cephalosporin disk that might be used as a screening test that could be used in conjunction with a 1-micrograms oxacillin disk. A 30-micrograms cefuroxime disk is proposed: strains with zones > or = 28 mm in diameter are predictably susceptible to cefotaxime and ceftriaxone, and those with smaller zones should be further studied to confirm resistance to either drug. A 30-micrograms ceftizoxime disk may also be used as a screening test with zones > or = 26 mm indicating susceptibility, but cefuroxime disks are preferred.

This article has been cited by other articles:

• Williams-Bouyer, N., Hernandez, A., Reisner, B. S. (1999). Predicting Susceptibility of Streptococcus pneumoniae to Ceftriaxone and Cefotaxime by Cefuroxime and Ceftizoxime Disk Diffusion Testing. J. Clin. Microbiol. 37: 3707-3710 [Abstract] [Full Text]  
• Jetté, L. P., Sinave, C. (1999). Use of an Oxacillin Disk Screening Test for Detection of Penicillin- and Ceftriaxone-Resistant Pneumococci. J. Clin. Microbiol. 37: 1178-1181 [Abstract] [Full Text]