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Journal of Clinical Microbiology, Apr 1997, 960-964, Vol 35, No. 4
D Sullivan, K Haynes, J Bille, P Boerlin, L Rodero, S Lloyd, M Henman and D Coleman
Candida dubliniensis is a recently identified chlamydospore-positive yeast
species associated with oral candidiasis in human immunodeficiency virus
(HIV)-infected (HIV+) patients and is closely related to Candida albicans.
Several recent reports have described atypical oral Candida isolates with
phenotypic and genetic properties similar to those of C. dubliniensis. In
this study 10 atypical chlamydospore-positive oral isolates from HIV+
patients in Switzerland, the United Kingdom, and Argentina and 1 isolate
from an HIV-negative Irish subject were compared to reference strains of C.
albicans and Candida stellatoidea and reference strains of C. dubliniensis
recovered from Irish and Australian HIV+ individuals. All 11 isolates were
phenotypically and genetically similar to and phylogenetically identical to
C. dubliniensis. These findings demonstrate that the geographical
distribution of C. dubliniensis is widespread, and it is likely that it is
a significant constituent of the normal oral flora with the potential to
cause oral candidiasis, particularly in immunocompromised patients.
Copyright © 1997 by the American Society for Microbiology. All rights reserved.
Widespread geographic distribution of oral Candida dubliniensis strains in human immunodeficiency virus-infected individuals
Department of Oral Medicine and Pathology, School of Dental Science, Trinity College, University of Dublin, Republic of Ireland.
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