In Vitro Activity of the New Triazole Voriconazole (UK-109,496) against Opportunistic Filamentous and Dimorphic Fungi and Common and Emerging Yeast Pathogens

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Journal of Clinical Microbiology, January 1998, p. 198-202, Vol. 36, No. 1
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activity of the New Triazole Voriconazole (UK-109,496) against Opportunistic Filamentous and Dimorphic Fungi and Common and Emerging Yeast Pathogens

Ana Espinel-Ingroff^*

Division of Infectious Diseases, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298-0049

Received 17 July 1997/Returned for modification 26 September 1997/Accepted 14 October 1997

The in vitro antifungal activity of a new triazole derivative, voriconazole, was compared with those of itraconazole and amphotericinB against 67 isolates of Aspergillus flavus, Aspergillus fumigatus,Bipolaris spp., Fusarium oxysporum, Fusarium solani, Pseudallescheriaboydii, Rhizopus arrhizus, Blastomyces dermatitidis, Histoplasmacapsulatum, and Sporothrix schenckii. The in vitro activitiesof voriconazole were also compared with those of amphotericinB, fluconazole, and itraconazole against 189 isolates of emergingand common yeast pathogens of Blastoschizomyces capitatus, Candida(13 species), Cryptococcus neoformans, Hansenula anomala, Rhodotorularubra, Saccharomyces cerevisiae, Sporobolomyces salmonicolor,and Trichosporon beigelii. MICs were determined according to aprocedure under evaluation by the National Committee for ClinicalLaboratory Standards (NCCLS) for broth microdilution testing offilamentous fungi and by the NCCLS M27-A broth microdilution methodfor yeasts. The in vitro activities of voriconazole were similarto or better than those of itraconazole and amphotericin B againstAspergillus spp., Fusarium spp., and P. boydii as well as againstB. dermatitidis and H. capsulatum. The activities of voriconazolewere also comparable to or better than those of amphotericin B,fluconazole, and itraconazole against most species of yeasts tested.Exceptions were certain isolates of R. rubra and S. salmonicolor.These results suggest that voriconazole has a wide spectrum ofactivity in vitro; its effectiveness in the treatment of humanmycoses is under evaluation in clinical trials.

^* Mailing address: Medical College of Virginia, Virginia Commonwealth University, P.O. Box 980049, Richmond, VA 23219. Phone:(804) 828-9711. Fax: (804) 828-3097.

Journal of Clinical Microbiology, January 1998, p. 198-202, Vol. 36, No. 1
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

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