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Journal of Clinical Microbiology, January 1998, p. 266-268, Vol. 36, No. 1
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Sporadic Emergence of Klebsiella pneumoniae Strains Resistant to Cefepime and Cefpirome in Greek Hospitals

L. S. Tzouvelekis,1,* E. Tzelepi,1 E. Prinarakis,1 M. Gazouli,1 A. Katrahoura,2 P. Giakkoupi,1 O. Paniara,3 and N. J. Legakis4

Department of Bacteriology, Hellenic Pasteur Institute,1 Microbiology Laboratory, "Metaxa" Anticancer Hospital,2 Microbiology Laboratory, "Evagelismos" General Hospital,3 and Department of Microbiology, School of Medicine, Athens University,4 Athens, Greece

Received 8 May 1997/Returned for modification 3 September 1997/Accepted 2 October 1997

The sporadic emergence of Klebsiella pneumoniae strains resistant to cefepime and cefpirome was observed in Greek hospitals during 1996. Examination of six epidemiologically distinct strains and clones selected in vitro provided indications that resistance is due to the cooperation of decreased outer membrane permeability and hydrolysis of the cephalosporins by SHV-5 beta -lactamase, which was produced in large amounts.

* Corresponding author. Mailing address: Department of Bacteriology, Hellenic Pasteur Institute, Vass. Sofias 127, Athens 11521, Greece. Phone: 0031-1-6462281. Fax: 0031-1-6423498. E-mail: LSTBACT{at}HOTMAIL.COM.

Journal of Clinical Microbiology, January 1998, p. 266-268, Vol. 36, No. 1
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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