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Journal of Clinical Microbiology, January 1998, p. 299-301, Vol. 36, No. 1
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Detection of Measles Virus mRNA from Autopsied Human Tissues

Yuko Katayama,1 Kiyoyasu Kohso,1 Akiyoshi Nishimura,2 Yoshitsugu Tatsuno,3 Morio Homma,4 and Hak Hotta1,*

Department of Microbiology,1 and Department of Legal Medicine,3 Kobe University School of Medicine, Chuo-ku, Kobe, Hyogo 650, Department of Legal Medicine, Shiga University of Medical Science, Ohtsu, Shiga 520-21,2 and Faculty of Home Economics, Kobe Women's University, Suma-ku, Kobe, Hyogo 654,4 Japan

Received 25 August 1997/Returned for modification 7 October 1997/Accepted 28 October 1997

By reverse transcription-PCR, measles virus (MV) mRNA was detected in the brain, kidney, spleen, liver, and lung tissues obtained from 23 (45.1%) of 51 autopsy subjects, with the detection rates of each tissue ranging from 8 to 20%. Sequence analysis revealed frequent mutations in the corresponding viral protein. These results suggest that MV mutants commonly persist in apparently healthy individuals.

* Corresponding author. Mailing address: Department of Microbiology, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650, Japan. Phone: 81-78-341-7451, ext. 3300. Fax: 81-78-351-6347. E-mail: hotta{at}kobe-u.ac.jp.

Journal of Clinical Microbiology, January 1998, p. 299-301, Vol. 36, No. 1
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1998 by the American Society for Microbiology. All rights reserved.