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Journal of Clinical Microbiology, October 1998, p. 3040-3043, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Hepatitis C in a Hemodialysis Unit: Molecular
Evidence for Nosocomial Transmission
S.
Le Pogam,1
D.
Le Chapois,2
R.
Christen,3
F.
Dubois,1
F.
Barin,1 and
A.
Goudeau1,*
Département de Microbiologie
Médicale et Moléculaire, CHU Bretonneau, 37044 Tours
Cedex,1
Service de Néphrologie
Hémodialyse, Centre Hospitalier de Bourges, 18016 Bourges,2 and
Observatoire
Océanologique
Station Zoologique, CNRS and Université
Pierre et Marie Curie, 06230 Villefranche sur
Mer,3 France
Received 30 March 1998/Returned for modification 28 May
1998/Accepted 26 June 1998
This study reports four cases of transmission of the rare hepatitis
C virus genotype 4 which occurred in a hemodialysis unit and originated
from a single source of infection. Phylogenetic analyses performed with
the NS5b domain showed that all four patients with secondary infections
were infected with virus strains very similar to that of the index
patient. Cross infections probably resulted from breaches in safety
precautions and lack of dialysis machine sterilization.
*
Corresponding author. Mailing address:
Département de Microbiologie Moléculaire et Médicale,
CHU Bretonneau, 2 Boulevard Tonnellé
37044 Tours Cedex, France.
Phone: 33 2 47 47 69 97. Fax: 33 2 47 47 36 10. E-mail:
goudeau{at}med.univ-tours.fr.
Journal of Clinical Microbiology, October 1998, p. 3040-3043, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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