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Journal of Clinical Microbiology, October 1998, p. 3040-3043, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Hepatitis C in a Hemodialysis Unit: Molecular Evidence for Nosocomial Transmission

S. Le Pogam,1 D. Le Chapois,2 R. Christen,3 F. Dubois,1 F. Barin,1 and A. Goudeau1,*

Département de Microbiologie Médicale et Moléculaire, CHU Bretonneau, 37044 Tours Cedex,1 Service de Néphrologie Hémodialyse, Centre Hospitalier de Bourges, 18016 Bourges,2 and Observatoire Océanologique---Station Zoologique, CNRS and Université Pierre et Marie Curie, 06230 Villefranche sur Mer,3 France

Received 30 March 1998/Returned for modification 28 May 1998/Accepted 26 June 1998

This study reports four cases of transmission of the rare hepatitis C virus genotype 4 which occurred in a hemodialysis unit and originated from a single source of infection. Phylogenetic analyses performed with the NS5b domain showed that all four patients with secondary infections were infected with virus strains very similar to that of the index patient. Cross infections probably resulted from breaches in safety precautions and lack of dialysis machine sterilization.

* Corresponding author. Mailing address: Département de Microbiologie Moléculaire et Médicale, CHU Bretonneau, 2 Boulevard Tonnellé---37044 Tours Cedex, France. Phone: 33 2 47 47 69 97. Fax: 33 2 47 47 36 10. E-mail: goudeau{at}med.univ-tours.fr.

Journal of Clinical Microbiology, October 1998, p. 3040-3043, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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