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Journal of Clinical Microbiology, October 1998, p. 3046-3047, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Rapid Diagnosis of Pulmonary Tuberculosis with the LCx Mycobacterium tuberculosis Assay and Comparison with Conventional Diagnostic Techniques

Peter Rohner,1,* Esther I. M. Jahn,2 Beatrice Ninet,1 Concetta Ionati,1 Rainer Weber,3 Raymond Auckenthaler,1 and Gaby E. Pfyffer2

Infectious Disease Division, Bacteriology Laboratory, University Hospital Geneva, 1211 Geneva,1 Swiss National Center for Mycobacteria, Department of Medical Microbiology, University of Zurich, 8028 Zurich,2 and Division of Infectious Disease, Department of Internal Medicine, University Hospital, 8091 Zurich,3 Switzerland

Received 16 December 1997/Returned for modification 9 March 1998/Accepted 2 July 1998

The LCx MTB amplification assay is a nucleic acid amplification test intended for the direct detection of Mycobacterium tuberculosis complex in respiratory specimens. We evaluated its performance on 2,001 consecutive respiratory specimens; 78 were culture positive for M. tuberculosis. Sensitivity, specificity, and positive and negative predictive values of this assay for all specimens compared to culture results were 88.5, 97.7, 60.5, and 99.5%, respectively. When referred to resolved clinical diagnosis of active tuberculosis, these values improved to 90.2, 98.4, 72.8, and 99.5%, respectively.

* Corresponding author. Mailing address: Division des Maladies Infectieuses, Laboratoire Central de Bactériologie, Hôpital Cantonal de Genève, 24 Rue Micheli-du-Crest, 1211 Geneva 14, Switzerland. Phone: 41 22 37 27 313. Fax: 41 22 37 27 304. E-mail: Peter.Rohner{at}hcuge.ch.

Journal of Clinical Microbiology, October 1998, p. 3046-3047, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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