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Journal of Clinical Microbiology, October 1998, p. 3088-3089, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Utility of Routine Testing of Bronchoalveolar Lavage Fluid for Cryptococcal Antigen

Stephen M. Kralovic1,2,* and Judith C. Rhodes3

Division of Infectious Diseases, Department of Internal Medicine,1 and Department of Pathology and Laboratory Medicine,3 University of Cincinnati College of Medicine, and Cincinnati Veterans Affairs Medical Center, Cincinnati,2 Ohio

Received 14 January 1998/Returned for modification 9 March 1998/Accepted 21 July 1998

All cryptococcal antigen (CrAg) testing performed at our institution between 1989 and 1994 was reviewed for utility of routinely testing of bronchoalveolar lavage fluid (BAL) for this antigen. Forty-two of 1,506 BAL specimens were positive. Seventeen of these were felt to represent false positives (sensitivity, 71%; positive predictive value, 0.59). The data on CrAg in cerebrospinal fluid and serum and the fungal culture and histological results of BAL specimens did not support continued, routine testing of BALs for CrAg to diagnose cryptococcosis.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, P.O. Box 670560, Cincinnati, OH 45267-0560. Phone: (513) 558-4704. Fax: (513) 558-2089. E-mail: Kralovic.Stephen_M{at}Cincinnati.va.gov.

Journal of Clinical Microbiology, October 1998, p. 3088-3089, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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