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Journal of Clinical Microbiology, November 1998, p. 3378-3381, Vol. 36, No. 11
Department of International Health,
Received 6 April 1998/Returned for modification 8 June
1998/Accepted 11 August 1998
By two PCR-based diagnostic methods, Plasmodium
malariae infections have been rediscovered at two foci in the
Sichuan province of China, a region where no cases of P. malariae have been officially reported for the last 2 decades. In
addition, a variant form of P. malariae which has a
deletion of 19 bp and seven substitutions of base pairs in the target
sequence of the small-subunit (SSU) rRNA gene was detected with high
frequency. Alignment analysis of Plasmodium sp. SSU rRNA
gene sequences revealed that the 5' region of the variant sequence is
identical to that of P. vivax or P. knowlesi and its 3' region is identical to that of P. malariae. The same sequence variations were also found in
P. malariae isolates collected along the Thai-Myanmar
border, suggesting a wide distribution of this variant form from
southern China to Southeast Asia.
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Sequence Variation in the Small-Subunit rRNA Gene
of Plasmodium malariae and Prevalence of Isolates with
the Variant Sequence in Sichuan, China
*
Corresponding author. Mailing address: Department of
International Health, Nagoya University School of Medicine, Nagoya
466-8550, Japan. Phone: 81-(52)-744-2113. Fax: 81-(52)-744-2114.
E-mail: hiko{at}med.nagoya-u.ac.jp.
Journal of Clinical Microbiology, November 1998, p. 3378-3381, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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