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Journal of Clinical Microbiology, November 1998, p. 3382-3384, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Evaluation of a Commercial PCR Kit for Diagnosis of Cytomegalovirus Infection of the Central Nervous System

Adriana Weinberg,1,* Debbie Spiers,1 Guan-Yung Cai,1 Christopher M. Long,2 Rita Sun,2 and Vince Tevere2

Pediatric Infectious Diseases, University of Colorado School of Medicine, Denver, Colorado,1 and Roche Molecular Systems, Inc., Branchburg, New Jersey2

Received 16 March 1998/Returned for modification 24 June 1998/Accepted 18 August 1998

We evaluated the AMPLICOR cytomegalovirus (CMV) PCR kit for the diagnosis of neurologic CMV infections on 43 positive and 112 negative archived cerebrospinal fluid specimens originally tested by an in-house PCR method. The AMPLICOR kit showed sensitivity and specificity of 95 and 100%, respectively, versus the home-grown assay, indicating its utility in this clinical setting.

* Corresponding author. Mailing address: University of Colorado Health Sciences Center, Campus Box C 227, 4200 East Ninth Ave., Denver, CO 80220. Phone: (303) 315-4624. Fax: (303) 315-6955. E-mail: adriana.weinberg{at}uchsch.edu.

Journal of Clinical Microbiology, November 1998, p. 3382-3384, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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