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Journal of Clinical Microbiology, November 1998, p. 3433-3434, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Comparison of Four Serological Tests To Determine the CagA or VacA Status of Helicobacter pylori Strains

Yoshio Yamaoka,1,2,* Tadashi Kodama,2 David Y. Graham,1 and Kei Kashima2

Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030,1 and Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kamikyo-ku, Kyoto, 602 Japan2

Received 8 April 1998/Returned for modification 3 August 1998/Accepted 18 August 1998

We compared four tests for antibodies to CagA or VacA, HelicoBlot 2.0, RIDA Blot Helicobacter, CHIRON RIBA H. pylori SIA, and an enzyme-linked immunosorbent assay using recombinant CagA. Immunoblot assays were accurate for determining Helicobacter pylori status but poor for determining CagA or VacA status (accuracy, 66 to 80% for CagA status and 34 to 67% for VacA status). None can be recommended for determining CagA or VacA status.

* Corresponding author. Mailing address: Veterans Affairs Medical Center (111D), 2002 Holcombe Blvd., Houston, TX 77030. Phone: (713) 794-7234. Fax: (713) 790-1040. E-mail: yoshio{at}wt.net.

Journal of Clinical Microbiology, November 1998, p. 3433-3434, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 1998 by the American Society for Microbiology. All rights reserved.