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Journal of Clinical Microbiology, December 1998, p. 3680-3682, Vol. 36, No. 12
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Heterogeneity of the PorB Protein in Serotype 22 Neisseria meningitidis

Rachel Urwin,1 Andrew J. Fox,2 Martin Musilek,3 Paula Kriz,3 and Martin C. J. Maiden1,*

Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford OX1 3PS,1 and Public Health Laboratory, Withington Hospital, Manchester M20 2LR,2 United Kingdom, and National Reference Laboratory for Meningococcal Infections, NIPH, Prague, Czech Republic3

Received 11 June 1998/Returned for modification 4 August 1998/Accepted 25 August 1998

The genetic diversity of porB genes from meningococcal isolates characterized as serotype 22 was investigated by gene sequencing. This procedure identified seven distinct porB sequences, demonstrating variation in the PorB protein recognized by the serotype 22 monoclonal antibody. This is consistent with the genetic heterogeneity of serotype 22 meningococci reported previously.

* Corresponding author. Mailing address: Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, South Parks Rd., Oxford OX1 3PS, United Kingdom. Phone and fax: 44 1865 271284. E-mail: martin.maiden{at}zoo.ox.ac.uk.

Journal of Clinical Microbiology, December 1998, p. 3680-3682, Vol. 36, No. 12
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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