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Journal of Clinical Microbiology, December 1998, p. 3718-3720, Vol. 36, No. 12
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Mink Lung Epithelial Cells: Unique Cell Line That Supports Influenza A and B Virus Replication

Stacey Schultz-Cherry,1,* Naomi Dybdahl-Sissoko,2 Martha McGregor,2 and Virginia S. Hinshaw2

Southeast Poultry Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Athens, Georgia 30605,1 and Department of Pathobiological Sciences, University of Wisconsin---Madison, Madison, Wisconsin 537062

Received 2 June 1998/Returned for modification 13 August 1998/Accepted 23 September 1998

We have demonstrated for the first time that a mink lung epithelial cell line (Mv1Lu) supports the replication of influenza A and B viruses, including the recently isolated H5N1 avian and human Hong Kong strains, to titers comparable to those in MDCK cells. These results suggest that Mv1Lu cells might serve as an alternative system for the isolation and cultivation of influenza A and B viruses and may be useful for vaccine development.

* Corresponding author. Mailing address: Southeast Poultry Research Laboratory, USDA-ARS, 934 College Station Rd., Athens, GA 30605. Phone: (706) 546-3464. Fax: (706) 546-3161. E-mail: sschultzcherry{at}sprynet.com.

Journal of Clinical Microbiology, December 1998, p. 3718-3720, Vol. 36, No. 12
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 1998 by the American Society for Microbiology. All rights reserved.