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Journal of Clinical Microbiology, February 1998, p. 589-591, Vol. 36, No. 2
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Comparison of Use of Cerebrospinal Fluid, Serum, and Throat Swab Specimens in Diagnosis of Enteroviral Acute Neurological Infection by a Rapid RNA Detection PCR Assay

Laurent Andréoletti,1,* Nathalie Blassel-Damman,1 Anny Dewilde,1 Louis Vallée,2 Robin Cremer,3 Didier Hober,1 and Pierre Wattré1

Laboratoire de Virologie,1 Service des Maladies Infectieuses Neurologiques Infantiles,2 and Service de Réanimation Pédiatrique,3 Centre Hospitalier Universitaire de Lille, 59037 Lille cedex, France

Received 4 June 1997/Returned for modification 2 September 1997/Accepted 4 November 1997

A PCR assay for detection of enterovirus RNA in multiple specimen types from patients with neurological infections was evaluated. Combined PCR assay of cerebrospinal fluid and serum (systemic specimens) was more sensitive than assaying either specimen alone in children but not in adults. Compared with PCR in systemic specimens, detection of enterovirus RNA in throat swabs showed a sensitivity of 62.5% and a specificity of 75.6%.

* Corresponding author. Mailing address: Laboratoire de Virologie, Bâtiment IRFPPS, Centre Hospitalier Régional Universitaire, 59037 LILLE Cedex, France. Phone: (33) 03 20 44 48 93. Fax: (33) 03 20 44 52 81. E-mail: landreoletti{at}chru-lille.fr.

Journal of Clinical Microbiology, February 1998, p. 589-591, Vol. 36, No. 2
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 1998 by the American Society for Microbiology. All rights reserved.