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Journal of Clinical Microbiology, February 1998, p. 595-597, Vol. 36, No. 2
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Failure of Quality Control Measures To Prevent Reporting of False Resistance to Imipenem, Resulting in a Pseudo-Outbreak of Imipenem-Resistant Pseudomonas aeruginosa

Yehuda Carmeli,1,* Karen Eichelberger,2 Don Soja,3 Joanna Dakos,2 Lata Venkataraman,2 Paola DeGirolami,2 and Matthew Samore1

Division of Infectious Diseases1 and Department of Pathology,2 Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, and Health Sciences Services, Merck & Co. Inc., West Point, Pennsylvania3

Received 21 July 1997/Returned for modification 12 September 1997/Accepted 13 November 1997

False results showing an outbreak of Pseudomonas aeruginosa with resistance to imipenem were traced to a defective lot of microdilution MIC testing panels. These panels contained two- to threefold lower concentrations of imipenem than expected and resulted in artifactual two- to fourfold increases in MICs of imipenem. The quality-control MIC results for Pseudomonas aeruginosa ATCC 27853 were 4 µg/ml, the highest value within the range recommended by the National Committee for Clinical Laboratory Standards. We recommend that this value be considered out of the quality-control range.

* Corresponding author. Mailing address: Division of Infectious Diseases, Beth Israel Deaconess Medical Center, West Campus, One Deaconess Rd., Boston, MA 02215. Phone: (617) 632-0760. Fax: (617) 632-0766. E-mail: ycarmeli{at}bidmc.harvard.edu.

Journal of Clinical Microbiology, February 1998, p. 595-597, Vol. 36, No. 2
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
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Copyright © 1998 by the American Society for Microbiology. All rights reserved.