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Journal of Clinical Microbiology, April 1998, p. 1113-1116, Vol. 36, No. 4
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection

Giuseppe Gerna,1,* Maurizio Zavattoni,1 Elena Percivalle,1 Paolo Grossi,2 Maria Torsellini,2 and M. Grazia Revello2

Viral Diagnostic Service, IRCCS Policlinico San Matteo,1 and Institute of Infectious Diseases, University of Pavia,2 Pavia, Italy

Received 9 October 1997/Returned for modification 21 November 1997/Accepted 22 December 1997

In 7 of 18 solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, HCMV antigenemia levels were unexpectedly found to rise significantly (P = 0.018) during a mean time of 7.3 ± 3.2 days after initiation of specific antiviral treatment, whereas corresponding levels of viremia dropped significantly (P = 0.043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients.

* Corresponding author. Mailing address: Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy. Phone: 39 382 502644 or 39 382 5026 34. Fax: 39 382 502599 or 39 382 423320. E-mail: virology{at}ipv36.unipv.it.

Journal of Clinical Microbiology, April 1998, p. 1113-1116, Vol. 36, No. 4
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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