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Journal of Clinical Microbiology, April 1998, p. 897-901, Vol. 36, No. 4
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Emergence of Multidrug Resistance in Ubiquitous and Dominant Pseudomonas aeruginosa Serogroup O:11

Panayotis T. Tassios,1 Vassiliki Gennimata,1 Anthony N. Maniatis,1 Caroline Fock,1,2 Nicholas J. Legakis,1,* and The Greek Pseudomonas aeruginosa Study Groupdagger

Department of Microbiology, Medical School, National University of Athens, Athens, Greece,1 and Department of Biomedical Laboratory Sciences, Uppsala University College of Health and Caring Sciences, Uppsala, Sweden2

Received 9 October 1997/Returned for modification 16 December 1997/Accepted 20 January 1998

The serotypes of 88 nonreplicate nosocomial Pseudomonas aeruginosa isolates from 11 Greek hospitals were studied in relation to their antibiotic susceptibilities. Rates of resistance to beta -lactams, aminoglycosides, and quinolones ranged from 31 to 65%, except for those to ceftazidime (15%) and imipenem (21%). Four serotypes were dominant: O:12 (25% of isolates), O:1 (17%), O:11 (16%), and O:6 (10%). Multidrug resistance rates in the major serogroups O:12 (91%) and O:11 (79%) were higher than those in serogroups O:1 (40%) and O:6 (43%). Further typing with respect to pulsed-field gel electrophoresis patterns following XbaI digestion of genomic DNA discriminated the isolates into 74 types. Pulsed-field gel electrophoresis revealed that the ubiquitous O:12 group was genetically homogeneous, since 95% of strains belonged to two clusters of genotypic similarity, while the O:11 strains, present in 8 of the 11 hospitals, were distributed among five such clusters. Therefore, apart from the already reported O:12 multidrug-resistant European clone, an O:11 population, characterized by a serotype known to be dominant in the environment and the hospital in several parts of the world, but previously not associated with multidrug resistance to antibiotics, has progressed to a multidrug-resistant state.

* Corresponding author. Mailing address: Department of Microbiology, Medical School, National University of Athens, M. Asias 75, 115 27 Athens, Greece. Phone: (301) 778-5638 or (301) 777-1139. Fax: (301) 778-5638. E-mail: njlegak{at}compulink.gr.

dagger The Greek Pseudomonas aeruginosa Study Group consisted of the following Directors of Microbiology Laboratories of the indicated hospitals: J. Douboyias (AHEPA), A. Katrahoura (Metaxa), S. Kitsou (Ag. Olga), C. Koutsia (Asklipieion Voulas), K. Bethymouti (Erythros Stavros), K. Intzes (401 Military Hospital), S. Dova (Ag. Savvas), C. Oikonomopoulou (Tzaneio), O. Paniara (Evangelismos), E. Papafrangas (Sismanogleio), and E. Papoutsaki (KAT).

Journal of Clinical Microbiology, April 1998, p. 897-901, Vol. 36, No. 4
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.