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Journal of Clinical Microbiology, May 1998, p. 1436-1438, Vol. 36, No. 5
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Use of Voriconazole in Treatment of Scedosporium apiospermum Infection: Case Report

Corrado Girmenia,* Giovanni Luzi, Monica Monaco, and Pietro Martino

Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza," Rome, Italy

Received 30 October 1997/Returned for modification 18 December 1997/Accepted 19 February 1998

We report a case of disseminated Scedosporium apiospermum infection in a neutropenic patient with acute myeloid leukemia. Due to progression of the mycosis after 7 days of amphotericin B lipid complex therapy and to high susceptibility of the mold to voriconazole in vitro, the patient was treated with intravenous voriconazole. After a few days of therapy, fever disappeared and skin lesions improved. However, the patient died after 1 month due to intestinal bleeding. Despite a negative outcome, this case seems to indicate a promising role for voriconazole in the treatment of S. apiospermum infections.

* Corresponding author. Mailing address: Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza," Via Benevento 6, 00161 Rome, Italy. Phone: 06/857951. Fax: 06/44241984. E-mail: GIRMENIA{at}BCE.MED.UNIROMA1.IT.

Journal of Clinical Microbiology, May 1998, p. 1436-1438, Vol. 36, No. 5
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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