Non-O157:H7 Stx2-Producing Escherichia coli Strains Associated with Sporadic Cases of Hemolytic-Uremic Syndrome in Adults

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Journal of Clinical Microbiology, June 1998, p. 1777-1780, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Non-O157:H7 Stx2-Producing Escherichia coli Strains Associated with Sporadic Cases of Hemolytic-Uremic Syndrome in Adults

R. Bonnet,¹ B. Souweine,² G. Gauthier,³ C. Rich,¹ V. Livrelli,¹ J. Sirot,¹ B. Joly,¹ and C. Forestier¹^,^*

Laboratoire de Bactériologie, Faculté de Médecine-Pharmacie, Université d'Auvergne-Clermont-1,¹ Service de Réanimation-Néphrologie, Centre Hospitalier Régional Universitaire,² and Société Genolife, Biopôle Clermont-Limagne,³ Clermont-Ferrand, France

Received 2 December 1997/Returned for modification 17 February 1998/Accepted 17 March 1998

From August 1996 to May 1997, six verotoxin-producing Escherichia coli (VTEC) strains were isolated from stool specimens ofadults suffering from hemolytic-uremic syndrome (HUS). All theisolates were stx₂ positive and belonged to different serotypes:O6:H4, O91:H10, O91:H21, O rough:H16, OX3:H $-$ , and O nontypeable:H $-$ .The enterohemolysin (Ehly)-encoding genes were detected in twoisolates, and none of the isolates harbors the intimin (Eae)-encodinggene. These findings suggest that stx₂-positive non-O157:H7 VTECis a major cause of HUS in adults and that several sources ofpathogens are responsible for local endemic infections.

^* Corresponding author. Mailing address: Laboratoire de Bactériologie, Faculté de Pharmacie, Université d'Auvergne, 28, placeH. Dunant, 63001 Clermont-Ferrand, France. Phone: (33) 4 73 6080 19. Fax: (33) 4 73 27 74 94. E-mail: Christiane.forestier{at}u-clermont1.fr.

Journal of Clinical Microbiology, June 1998, p. 1777-1780, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

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